Our new Crystal clear+ tissue clearing system is the only technique that delipidates samples without any adjust in morphology and with negligible impact on structural integrity.

Megatome is actually a vibrating microtome intended to part a wide number of samples, from organoids and biopsy samples to expanded rodent brains and intact human organs. With high blade vibrating frequency and minimized blade deflection, Megatome enables higher-throughput tissue sectioning with uniform surface area profile, and also small tissue destruction and information loss.

Antibodies may perhaps choose months to diffuse as a result of only a few millimeters of tissue, by using a steep labeling gradient from area to Main.

Megatome is suitable for precision: the blade vibrates at an increased frequency and bigger amplitude array than other microtomes, and contains a exclusive deflection Management system.

SE works by using a rotational electric powered subject to disperse hugely electromobile molecules (including antibodies or surfactant micelles) through a porous sample without having harmful electrically charged structures throughout the tissue. This allows two-four working day clearing of intact organs,

Our preformulated EasyIndex Alternative raises and homogenize the refractive index of delipidated tissue samples, rendering them fully transparent. This allows light-weight penetration into your sample and ensures the acquisition of megatomi.com superior-resolution, in-concentration picture information.

Megatome can be a novel microtome that allows for prime-precision sectioning of a wide array of tissue samples – from organoids, to arrays of animal organs, to intact human brain hemispheres – with negligible tissue hurt and information decline.

It’s time and energy to improve your microtome to Megatome. With exact large-frequency slicing for an unmatched range of sample measurements and types – from organoids and tumors to expanded tissues, sample arrays, and intact primate organs – Megatome is optimized for varied programs.

Absolutely delipidate complete mouse brains or comparably sized samples in only one day with SmartBatch+, or in a single week with our passive clearing package.

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Leverage the Distinct+ tissue clearing strategy, in conjunction with eFLASH and patented stochastic electrotransport systems, to quickly very clear and label total organs. Vital highlights and features contain:

Our novel Defend tissue preservation procedure types intramolecular bonds employing polyfunctional, flexible epoxides to stabilize tissue architecture and safeguard the sample’s endogenous fluorescence, protein antigenicity and nucleic acids.